[Combinations of mezlocillin with other antibiotics. A review of in vitro laboratory studies (author's transl)].

Thirteen publications concerning combinations of mezlocillin with other antibiotics are reviewed, with special attention to antibiotics at present available in France. A fairly large number of different methods were used by the authors, making a comparative study extremely difficult. Most studies dealt with mezlocillin-aminoglycoside combinations against enterobacteriacaea and Pseudomonas aeruginosa : the effect was predominantly synergistic, but a few antagonistic effects are reported. The results on other groups of bacteria and with other antibiotics are more scattered. It was sometimes useful to combine mezlocillin with a cephalosporin. A synergistic effect with fosfomycin was found against Serratia.