噬菌体λDNA在需要胸腺嘧啶的大肠杆菌K-12菌株中的复制方向。胸腺嘧啶核苷浓度的影响。
Direction of bacteriophage lambda DNA replication in a thymine requiring Escherichia coli K-12 strain. Effect of thymidine concentration.
作者信息
Valenzuela M S, Inman R B
出版信息
Nucleic Acids Res. 1981 Dec 21;9(24):6975-84. doi: 10.1093/nar/9.24.6975.
Abstract
The direction of replication was established for the first round of bacteriophage lambda DNA replication in thymine requiring E. coli K-12 cells exposed to different concentrations of thymidine. It was found that a dramatic decrease in the proportion of bidirectionally replicating molecules followed a decrease in the concentration of thymidine. Moreover, the rightward mode of replication appears to be exclusively favored in unidirectionally replicating molecules found at low concentrations of thymidine.
摘要
在暴露于不同浓度胸苷的需要胸腺嘧啶的大肠杆菌K-12细胞中，确定了噬菌体λDNA第一轮复制的复制方向。结果发现，随着胸苷浓度的降低，双向复制分子的比例急剧下降。此外，在低浓度胸苷下发现的单向复制分子中，似乎只倾向于向右复制模式。
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