Ilfeld D, Weil S, Kuperman O
Arthritis Rheum. 1982 Jan;25(1):38-41. doi: 10.1002/art.1780250106.
We tested the clinical and immunoregulatory effects of peritoneal dialysis and hemodialysis on a patient with familial Mediterranean fever (FMF), amyloidosis, and chronic renal failure. His frequency of FMF attacks during maintenance hemodialysis (no attacks in 21 months) was significantly less than during conservative medical therapy (10 attacks in 14 months, P less than 0.00002) or during intermittent peritoneal dialysis (3 attacks in 4 months, P less than 0.004). His mean (+/-SE) percentage suppressor cell function was significantly (P less than 0.001) higher during hemodialysis (53 +/- 5) than during conservative medical therapy (4 +/- 3) or during peritoneal dialysis (2 +/- 7) and was similar to the healthy untreated volunteers (46 +/- 3). This suggests that his suppressor cell deficiency may be associated with the pathogenesis of his disease. One possible mechanism by which hemodialysis ameliorates FMF may be the correction of a suppressor cell abnormality.
我们测试了腹膜透析和血液透析对一名患有家族性地中海热（FMF）、淀粉样变性和慢性肾衰竭患者的临床及免疫调节作用。在维持性血液透析期间（21个月无发作），他的FMF发作频率显著低于保守药物治疗期间（14个月发作10次，P<0.00002）或间歇性腹膜透析期间（4个月发作3次，P<0.004）。在血液透析期间，他的平均（±标准误）抑制细胞功能百分比显著高于保守药物治疗期间（4±3）或腹膜透析期间（2±7）（P<0.001），且与未接受治疗的健康志愿者相似（46±3）。这表明他的抑制细胞缺陷可能与疾病的发病机制有关。血液透析改善FMF的一种可能机制可能是纠正抑制细胞异常。
