Melamed I, Shemer Y, Zakuth V, Tzehoval E, Pras M, Spirer Z
Clin Exp Immunol. 1983 Sep;53(3):659-62.
Familial Mediterranean fever (FMF) is a genetic disorder with an obscure aetiology. In attempts to investigate a possible immunoregulatory imbalance involved in this disease we tested 24 FMF patients for suppressor T cell activity and for chemotaxis of mononuclear cells. The suppressor T cell activity and chemotaxis were decreased in untreated FMF patients as compared to colchicine treated patients or normal controls. Amyloid FMF patients manifested significantly increased chemotactic activity, while the suppressor T cell activity was normal. This finding may extend our knowledge concerning the immune mechanism involved in FMF.
家族性地中海热（FMF）是一种病因不明的遗传性疾病。为了研究该疾病可能涉及的免疫调节失衡，我们对24例FMF患者进行了抑制性T细胞活性和单核细胞趋化性检测。与秋水仙碱治疗的患者或正常对照组相比，未经治疗的FMF患者的抑制性T细胞活性和趋化性降低。淀粉样变FMF患者的趋化活性显著增加，而抑制性T细胞活性正常。这一发现可能会扩展我们对FMF所涉及免疫机制的认识。
