Sasaki K, Nakano R, Kadoya Y, Iwao M, Shima K, Sowa M
Br J Obstet Gynaecol. 1982 Mar;89(3):195-8. doi: 10.1111/j.1471-0528.1982.tb03612.x.
Dehydroepiandrosterone sulphate (DHEA-S) was given intravenously twice a week after 38 weeks gestation to ripen the uterine cervix in 20 nulliparae and 24 parous women who subsequently went into labour at term. The condition of the uterine cervix was assessed by Bishop scoring. The increase in the score in nulliparous women given DHEA-S was significantly greater than that in the control group, who were given placebo injections, on the 7th, 14th and 21st days. The increase in the parous women was significant only on the 7th day. In nulliparous women the dilatation, effacement and consistency improved significantly, while in the parous women the effect of DHEA-S was apparent only in the consistency. The duration of labour was significantly shortened by treatment with DHEA-S in nulliparae but this effect was not found in parous women. The interval between the first administration of DHEA-S and the onset of labour in nulliparae was significantly shorter than that in the control group. There were no serious side effects or complications. Our results suggest that DHEA-S may be used safely and effectively to ripen the uterine cervix and to trigger the onset of labour in late pregnancy.
在妊娠38周后，对20名未产妇和24名经产妇静脉注射硫酸脱氢表雄酮（DHEA-S），每周两次，以促宫颈成熟，这些产妇随后足月分娩。通过Bishop评分评估宫颈状况。在第7天、14天和21天，接受DHEA-S治疗的未产妇评分增加显著大于接受安慰剂注射的对照组。经产妇仅在第7天评分增加显著。在未产妇中，宫颈扩张、消退和质地均显著改善，而在经产妇中，DHEA-S的作用仅在宫颈质地方面明显。DHEA-S治疗显著缩短了未产妇的产程，但在经产妇中未发现此效果。未产妇首次注射DHEA-S至分娩开始的间隔时间显著短于对照组。未出现严重副作用或并发症。我们的结果表明，DHEA-S可安全有效地用于促宫颈成熟并引发晚期妊娠的分娩。
