Cassel S, Robson L, Rosse C
Anat Rec. 1978 May;191(1):47-53. doi: 10.1002/ar.1091910105.
Bone marrow from adult rats fed a vitamin B6 deficient diet for two weeks was found to have reduced numbers of neutrophils, erythroid cells and small lymphocytes. The numbers of transitional cells were not reduced. Since the small lymphocyte population in the bone marrow consists of B cells and null cells in approximately the same proportion, it was concluded that both cell types were reduced as a result of the deficiency. A complete recovery in the cellularity of the bone marrow was brought about by returning the vitamin B6 deficient animals to a normal diet for four weeks. Other effects of the two-week vitamin B6 deficient diet included a failure to gain weight, a decrease in thymus weight and a reduction in the numbers of white blood cells in the peripheral blood. All of these defects were corrected after the animals had been fed a normal diet for four weeks.
研究发现，喂食缺乏维生素B6的饮食两周的成年大鼠，其骨髓中的中性粒细胞、红细胞和小淋巴细胞数量减少。过渡细胞的数量未减少。由于骨髓中的小淋巴细胞群体由比例大致相同的B细胞和裸细胞组成，因此得出结论，这两种细胞类型均因缺乏维生素B6而减少。将缺乏维生素B6的动物恢复正常饮食四周后，骨髓细胞数量完全恢复。两周缺乏维生素B6饮食的其他影响包括体重未增加、胸腺重量减轻以及外周血白细胞数量减少。在动物喂食正常饮食四周后，所有这些缺陷均得到纠正。
