粗糙脉孢菌脂肪酸降解过程中酰基辅酶A合成酶和羟酰基辅酶A脱氢酶的诱导作用
Induction of acyl coenzyme A synthetase and hydroxyacyl coenzyme A dehydrogenase during fatty acid degradation in Neurospora crassa.
作者信息
Hii V, Courtright J B
出版信息
J Bacteriol. 1982 May;150(2):981-3. doi: 10.1128/jb.150.2.981-983.1982.
Abstract
Neurospora crassa is able to use long-chain fatty acids as the sole carbon and energy source. After growth on oleate there was nearly a 10-fold induction of the acyl coenzyme A (CoA) synthetase and a fivefold increase in the activity of the 3-hydroxyacyl-CoA dehydrogenase. There was a slight induction of the enoyl-CoA hydratase and 3-ketoacyl-CoA thiolase, but no apparent induction of the flavin-linked acyl-CoA dehydrogenase. These noncoordinate changes in the fatty acid degradation enzymes suggest that they are not organized into a multienzyme complex as is found in bacteria.
摘要
粗糙脉孢菌能够将长链脂肪酸作为唯一的碳源和能源。在油酸上生长后，酰基辅酶A（CoA）合成酶的诱导率接近10倍，3-羟酰基辅酶A脱氢酶的活性增加了5倍。烯酰辅酶A水合酶和3-酮酰辅酶A硫解酶有轻微诱导，但黄素连接的酰基辅酶A脱氢酶没有明显诱导。脂肪酸降解酶的这些非协同变化表明，它们不像在细菌中那样被组织成多酶复合物。
相似文献
1
Induction of acyl coenzyme A synthetase and hydroxyacyl coenzyme A dehydrogenase during fatty acid degradation in Neurospora crassa.粗糙脉孢菌脂肪酸降解过程中酰基辅酶A合成酶和羟酰基辅酶A脱氢酶的诱导作用
J Bacteriol. 1982 May;150(2):981-3. doi: 10.1128/jb.150.2.981-983.1982.
2
Evidence for a complex of three beta-oxidation enzymes in Escherichia coli: induction and localization.大肠杆菌中三种β-氧化酶复合体的证据：诱导与定位
J Bacteriol. 1977 Nov;132(2):532-40. doi: 10.1128/jb.132.2.532-540.1977.
3
Inducible beta-oxidation pathway in Neurospora crassa.粗糙脉孢菌中的可诱导β-氧化途径。
J Bacteriol. 1985 Jan;161(1):153-7. doi: 10.1128/jb.161.1.153-157.1985.
4
Fatty acid degradation in Caulobacter crescentus.新月柄杆菌中的脂肪酸降解
J Bacteriol. 1986 Oct;168(1):49-54. doi: 10.1128/jb.168.1.49-54.1986.
5
The beta-oxidation system in catalase-free microbodies of the filamentous fungus Neurospora crassa. Purification of a multifunctional protein possessing 2-enoyl-CoA hydratase, L-3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxyacyl-CoA epimerase activities.丝状真菌粗糙脉孢菌无过氧化氢酶微体中的β-氧化系统。一种具有2-烯酰辅酶A水合酶、L-3-羟酰基辅酶A脱氢酶和3-羟酰基辅酶A表异构酶活性的多功能蛋白的纯化。
J Biol Chem. 1991 Jul 15;266(20):13110-7.
6
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein.大鼠肝脏线粒体中的新型脂肪酸β-氧化酶。II. 烯酰辅酶A水合酶/3-羟酰基辅酶A脱氢酶/3-酮酰基辅酶A硫解酶三功能蛋白的纯化及特性
J Biol Chem. 1992 Jan 15;267(2):1034-41.
7
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha).缺乏过氧化物酶体增殖物激活受体α（PPARα）的小鼠中脂肪酸代谢酶的组成型表达改变。
J Biol Chem. 1998 Mar 6;273(10):5678-84. doi: 10.1074/jbc.273.10.5678.
8
The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels.酿酒酵母FAT1基因编码一种酰基辅酶A合成酶，该酶是维持超长链脂肪酸水平所必需的。
J Biol Chem. 1999 Feb 19;274(8):4671-83. doi: 10.1074/jbc.274.8.4671.
9
Functions and organization of peroxisomal beta-oxidation.过氧化物酶体β-氧化的功能与组织
Ann N Y Acad Sci. 1996 Dec 27;804:99-115. doi: 10.1111/j.1749-6632.1996.tb18611.x.
10
Purification and characterization of fatty acid beta-oxidation enzymes from Caulobacter crescentus.新月柄杆菌脂肪酸β-氧化酶的纯化与特性分析
J Bacteriol. 1990 Feb;172(2):997-1004. doi: 10.1128/jb.172.2.997-1004.1990.
引用本文的文献
1
Physiological role of Acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa.酰基辅酶A合成酶同源物在粗糙脉孢菌脂质代谢中的生理作用
Eukaryot Cell. 2013 Sep;12(9):1244-57. doi: 10.1128/EC.00079-13. Epub 2013 Jul 19.
2
Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.控制丝状真菌构巢曲霉中脂肪酸分解代谢和过氧化物酶体功能的调控基因。
Eukaryot Cell. 2006 May;5(5):794-805. doi: 10.1128/EC.5.5.794-805.2006.
3
Preparation of cell-free extracts and the enzymes involved in fatty acid metabolism in Syntrophomonas wolfei.嗜互营单胞菌无细胞提取物及脂肪酸代谢相关酶的制备
J Bacteriol. 1986 Jul;167(1):179-85. doi: 10.1128/jb.167.1.179-185.1986.
4
Inducible beta-oxidation pathway in Neurospora crassa.粗糙脉孢菌中的可诱导β-氧化途径。
J Bacteriol. 1985 Jan;161(1):153-7. doi: 10.1128/jb.161.1.153-157.1985.
本文引用的文献
1
The production of acetate from fatty acids by Neurospora.粗糙脉孢菌从脂肪酸中产生乙酸盐的过程。
J Bacteriol. 1950 Aug;60(2):185-90. doi: 10.1128/jb.60.2.185-190.1950.
2
Limitations of the phenazine methosulphate assay for succinic and related dehydrogenases.吩嗪硫酸甲酯法测定琥珀酸及相关脱氢酶的局限性。
Nature. 1962 Mar 31;193:1256-8. doi: 10.1038/1931256a0.
3
Regulation of fatty acid degradation in Escherichia coli: isolation and characterization of strains bearing insertion and temperature-sensitive mutations in gene fadR.大肠杆菌中脂肪酸降解的调控：fadR基因中携带插入突变和温度敏感突变菌株的分离与鉴定
J Bacteriol. 1980 May;142(2):621-32. doi: 10.1128/jb.142.2.621-632.1980.
4
The induction of the enzymes of fatty acid degradation in Escherichia coli.大肠杆菌中脂肪酸降解酶的诱导
Biochem Biophys Res Commun. 1967 Oct 11;29(1):28-33. doi: 10.1016/0006-291x(67)90535-9.
5
Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver.禽肝胞质乙酰乙酰辅酶A硫解酶的分子与催化特性
J Biol Chem. 1973 Apr 10;248(7):2275-84.
6
ato Operon: a highly inducible system for acetoacetate and butyrate degradation in Escherichia coli.阿托操纵子：大肠杆菌中用于乙酰乙酸和丁酸降解的高度可诱导系统。
Eur J Biochem. 1972 Sep 25;29(3):553-62. doi: 10.1111/j.1432-1033.1972.tb02021.x.
7
Limiting availability of binding sites for dehydrogenases on the cell membrane of Escherichia coli.限制脱氢酶在大肠杆菌细胞膜上的结合位点可用性。
Proc Natl Acad Sci U S A. 1972 Apr;69(4):925-9. doi: 10.1073/pnas.69.4.925.
8
Saturated fatty acid requirer of Neurospora crassa.粗糙脉孢菌的饱和脂肪酸需求者。
J Bacteriol. 1971 Apr;106(1):174-82. doi: 10.1128/jb.106.1.174-182.1971.
9
Enzyme localization in the inner and outer mitochondrial membranes.酶在线粒体内膜和外膜中的定位。
Biochem Biophys Res Commun. 1968 May 10;31(3):368-78. doi: 10.1016/0006-291x(68)90485-3.
10
Five different enzymatic activities are associated with the multienzyme complex of fatty acid oxidation from Escherichia coli.五种不同的酶活性与来自大肠杆菌的脂肪酸氧化多酶复合体相关。
J Bacteriol. 1979 Jan;137(1):469-73. doi: 10.1128/jb.137.1.469-473.1979.
Zotero 插件