Kakiuchi S, Tagawa S, Watanabe K, Kosaka Y, Takezawa H
Jpn J Antibiot. 1982 Jan;35(1):212-21.
Serum and urinary levels of PIPC (sodium piperacillin) in patients with liver disease were investigated. Serum and urinary levels of PIPC are affected by the degree of liver disease which is estimated most exactly by KICG, and it is available for determination of dose and administration interval. When PIPC was administered intravenously at a dose of 2 g, serum level in patients with liver disease was showed high and prolonged. Therefore this is convenient for PIPC of which biological half life is comparatively short. In patients with serious liver cirrhosis, PIPC is probably cumulated by continuous administration and in this case, dose and administration interval will be needed to regulate.
对肝病患者哌拉西林钠（PIPC）的血清和尿液水平进行了研究。PIPC的血清和尿液水平受肝病程度的影响，而肝病程度通过KICG能最准确地评估，这对于确定剂量和给药间隔是有用的。当以2g的剂量静脉注射PIPC时，肝病患者的血清水平显示较高且持续时间长。因此，这对于生物半衰期相对较短的PIPC来说很方便。在严重肝硬化患者中，持续给药可能会导致PIPC蓄积，在这种情况下，需要调整剂量和给药间隔。
