Kingsbury P A, Reid J F
Vet Rec. 1981 Oct 31;109(18):404-7. doi: 10.1136/vr.109.18.404.
Oxfendazole was administered in paste or drench formulations to groups of five horses carrying naturally acquired worm burdens. At a dose rate of 10 mg/kg the efficacy of either formulation appeared similar. One hundred per cent of the adult populations of the following genera was removed: Parascaris, Oxyuris, Strongylus (S edentatus, S vulgaris), Triodontophorus and Trichostrongylus axei. Efficacy against adult small strongyles, adult Habronema microstoma and immature Oxyuris equi was in the region of 96 to 99 per cent. The level of efficacy against immature small strongyles was at least 74 to 75 per cent, against fourth stage larvae of S vulgaris in the mesenteric arteries between 83 and 88 per cent and against fourth stage S edentatus in flank lesions between 97 and 99 per cent. Early fifth stage sheathed S vulgaris larvae in arteries were less susceptible. The drug failed to remove very young parascaris and habronema and had no effect against Anoplocephala perfoliata and various instars of Gasterophilus intestinalis and G nasalis. Hatching tests on strongyle eggs passed in the faeces indicated that 24 hours must elapse before all become sterile.
将氧苯达唑制成膏剂或水剂，给五组自然感染蠕虫的马投喂。剂量为10毫克/千克时，两种剂型的疗效似乎相似。以下属的成虫种群清除率达100%：蛔虫属、尖尾线虫属、圆线虫属（定居圆线虫、普通圆线虫）、三齿线虫属和马副蛔虫。对小型圆线虫成虫、小口柔线虫成虫和未成熟的马尖尾线虫的疗效在96%至99%之间。对未成熟小型圆线虫的疗效水平至少为74%至75%，对肠系膜动脉中普通圆线虫第四期幼虫的疗效为83%至88%，对胁腹病变中定居圆线虫第四期幼虫的疗效为97%至99%。动脉中早期第五期带鞘普通圆线虫幼虫较不敏感。该药物未能清除极幼小的蛔虫和柔线虫，对叶状裸头绦虫以及肠胃蝇和鼻胃蝇的各龄幼虫均无作用。对粪便中排出的圆线虫虫卵进行的孵化试验表明，所有虫卵必须经过24小时才会全部失去活力。
