Riemenschneider T A, Brenner R A, Wikman-Coffelt J, Mason D T
Am Heart J. 1982 May;103(5):834-9. doi: 10.1016/0002-8703(82)90396-9.
We performed a chronologic investigation of left (LV) and right (RV) ventricular myosin ATPase activity and hemodynamics in newborn lambs. We found an elevation in myosin ATPase activity for the LV, which was achieved by 6 to 8 weeks of age and which correlated directly with increasing ventricular stroke work. Myosin ATPase activity did not increase with age for the RV, a finding which was associated with a postnatal decrease in ventricular stroke work. These findings may represent an important postnatal adaptation of newborn myocardium to the demands of extrauterine life.
我们对新生羔羊的左心室（LV）和右心室（RV）肌球蛋白ATP酶活性及血流动力学进行了一项时间顺序研究。我们发现左心室肌球蛋白ATP酶活性升高，在6至8周龄时达到这一水平，且与心室搏功增加直接相关。右心室肌球蛋白ATP酶活性并未随年龄增加，这一发现与出生后心室搏功降低有关。这些发现可能代表了新生心肌对宫外生活需求的一种重要的出生后适应性变化。
