Johnson A E
Am J Vet Res. 1982 Apr;43(4):718-23.
The efficacy of 2 mineral-vitamin supplements in preventing or alleviating initial pyrrolizidine alkaloid (PA) toxicosis in cattle was tested. Three groups of calves were fed 1 of the 2 supplements plus tansy ragwort (Senecio jacobaea) containing PA and 2 groups of calves were fed tansy ragwort without the supplement. Toxicity comparisons were based on differences in observed clinical signs, serum enzyme changes, survival time of calves, and histopathologic examination of hepatic tissue. Typical tansy ragwort toxicosis terminating in death developed in all calves. There were no marked differences in responses of the groups of calves. Seemingly, the supplements did not afford protection or alleviate tansy ragwort-related PA toxicosis in calves.
对两种矿物质 - 维生素补充剂预防或减轻牛初始吡咯里西啶生物碱（PA）中毒的功效进行了测试。三组小牛分别喂食两种补充剂中的一种加含PA的千里光（欧洲千里光），两组小牛喂食不含补充剂的千里光。毒性比较基于观察到的临床症状差异、血清酶变化、小牛存活时间以及肝组织的组织病理学检查。所有小牛均出现典型的以死亡告终的千里光中毒。各小牛组的反应没有明显差异。显然，这些补充剂并未为小牛提供保护或减轻与千里光相关的PA中毒。
