系膜IgA肾病患者伴刀豆球蛋白A诱导的抑制性T淋巴细胞功能丧失。

Loss of concanavalin A induced suppressor T-lymphocyte function in patients with mesangial IgA nephritis.

作者信息

Woo K T, Tan Y O, Lau Y K, Ng S L, Chew T S, Chan S H, Lim C H

出版信息

Ann Acad Med Singap. 1982 Jan;11(1):24-7.

PMID:6462097

Abstract

Using the method of concanavalin A (Con a) inducible suppressor activity the peripheral mononuclear cells (PMC) of 17 patients with Mesangial IgA nephritis, 13 patients with idiopathic mesangial proliferative glomerulonephritis but with no IgA deposits on immunofluorescence (Non-IgA nephritis) and 18 healthy subjects were studied. DNA synthesis was measured by incorporation of 3H Thymidine. The mean suppression index (S.I.) of 0.94 +/- 0.08 (SEM) in the IgA nephritic patients was significantly different from that of the non-IgA nephritic patients (0.67 +/- 0.05) (P less than 0.01) as well as the group of normal healthy controls (0.64 +/- 0.05) (P less than 0.0025). The data show that patients with IgA nephritis have abnormal suppressor cell function and suggest an autoimmune basis in the pathogenesis of IgA nephritis.

摘要

采用刀豆蛋白A（Con a）诱导抑制活性的方法，对17例系膜IgA肾病患者、13例免疫荧光检查无IgA沉积的特发性系膜增生性肾小球肾炎患者（非IgA肾病）及18名健康受试者的外周血单个核细胞（PMC）进行了研究。通过掺入3H胸腺嘧啶核苷来测定DNA合成。IgA肾病患者的平均抑制指数（S.I.）为0.94±0.08（标准误），与非IgA肾病患者（0.67±0.05）（P＜0.01）以及正常健康对照组（0.64±0.05）（P＜0.0025）相比有显著差异。数据表明，IgA肾病患者存在抑制细胞功能异常，提示IgA肾病发病机制中有自身免疫基础。