Chan S H, Ong B T, Wong P T
Neurosci Lett. 1984 Jun 1;47(1):57-62. doi: 10.1016/0304-3940(84)90386-0.
In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) greater than hypotension (28.9%) greater than bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart.
在戊巴比妥麻醉的大鼠中，向疑核单侧微量注射（500纳克）选择性胞体兴奋性毒素海人酸，可显著抑制动脉血压、心率和心脏收缩力。在注射后60分钟末，这种心血管抑制的程度依次为心脏收缩力降低（50.7%）大于低血压（28.9%）大于心动过缓（20.8%）。我们得出结论，疑核可能通过对心脏的负性变时和变力作用来控制心脏活动。
