Lopitaux R, Hermet R, Sirot J, Cluzel M
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):563-6.
Urinary tract infections in the elderly are severe and intractable, often justifying the use of aminoglycosides. We studied the effects of dibekacin in 28 patients, with no vesical catheter, whose average age was 78 +/- 6.1 years. The drug was given for ten days, in an average dose of 2.1 mg/kg/day divided into two injections. Serum concentration was measured after one hour on day 1 and after eight hours on days 1 and 10. Causative pathogens, all susceptible to dibekacin, were: 18 E. coli, 3 Proteus mirabilis, 3 Klebsiella, 1 Enterobacter cloacae, 1 Citrobacter and 2 Staphylococci. MIC and MBC of dibekacin were determined for each microorganism. Dibekacin was discontinued in four cases on day three because of persistent bacteriuria. Ten days after treatment end, 19 patients were cured, 4 had a relapse and 1 was reinfected. Average serum concentration of dibekacin, measured after eight hours, increased from 0.77 +/- 0.48 micrograms/ml on day 1 to 1.78 +/- 1.22 microgram/ml on day 10 (t = 4.42; p less than 0.0005), while, over the same period, there was no significant change in serum creatinine.
老年人的尿路感染严重且难以治疗，常常有理由使用氨基糖苷类药物。我们对28例未插膀胱导尿管、平均年龄为78±6.1岁的患者研究了双去氧卡那霉素的效果。给药10天，平均剂量为2.1mg/kg/天，分两次注射。在第1天1小时后以及第1天和第10天8小时后测量血清浓度。致病病原体均对双去氧卡那霉素敏感，分别为：18株大肠杆菌、3株奇异变形杆菌、3株克雷伯菌、1株阴沟肠杆菌、1株柠檬酸杆菌和2株葡萄球菌。对每种微生物测定了双去氧卡那霉素的MIC和MBC。4例患者在第3天因持续菌尿而停用双去氧卡那霉素。治疗结束10天后，19例患者治愈，4例复发，1例再感染。8小时后测量的双去氧卡那霉素平均血清浓度从第1天的0.77±0.48μg/ml增加到第10天的1.78±1.22μg/ml（t=4.42；p<0.0005），而在同一时期，血清肌酐没有显著变化。
