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溴量法氧化后某些青霉素的极谱行为及测定

Polarographic behaviour and determination of some penicillins after bromometric oxidation.

作者信息

Rizk M, Walash M I, Abou-Ouf A A, Belal F

出版信息

Pharm Weekbl Sci. 1984 Jun 22;6(3):114-7. doi: 10.1007/BF01963001.

DOI:10.1007/BF01963001
PMID:6462878
Abstract

The direct current polarographic behaviour of the bromometric oxidation product of certain penicillins has been investigated. The oxidized products give a well defined cathodic wave with E1/2 = 0.6 V vs saturated calomel electrode (SCE). The nature of the wave and the electrode reaction have been evaluated. A procedure was developed for investigation of the penicillins either in the pure state or in dosage forms. The results were compared with those obtained with the official methods.

摘要

对某些青霉素的溴氧化产物的直流极谱行为进行了研究。氧化产物给出了一个明确的阴极波,相对于饱和甘汞电极(SCE),其半波电位E1/2 = 0.6V。对该波的性质和电极反应进行了评估。开发了一种用于研究纯态或剂型青霉素的方法。将结果与用官方方法获得的结果进行了比较。

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本文引用的文献

1
Polarographic determination of ampicillin in capsules and tablets.
Talanta. 1979 Nov;26(11):1039-40. doi: 10.1016/0039-9140(79)80013-2.
2
Fluorometric analysis of ampicillin in biological fluids.生物体液中氨苄西林的荧光分析
J Pharm Sci. 1971 May;60(5):728-32. doi: 10.1002/jps.2600600514.
3
N-bromosuccinimide assay of penicillins and cephalosporins.青霉素和头孢菌素的N-溴代琥珀酰亚胺测定法。
J Pharm Sci. 1976 Feb;65(2):300-1. doi: 10.1002/jps.2600650232.
4
DC polarography of cephradine and its application to capsules.头孢拉定的示波极谱法及其在胶囊中的应用。
J Assoc Off Anal Chem. 1979 May;62(3):556-9.
5
Demonstration of penicillamine as a product in benzylpenicillenic acid degradation in neutral media using differential pulse polarography.使用差分脉冲极谱法证明青霉胺是苄青霉素酸在中性介质中降解的产物。
J Pharm Sci. 1978 Mar;67(3):302-5. doi: 10.1002/jps.2600670306.