Yamamoto M, Arishima K, Eguchi Y, Mochizuki K
Proc Soc Exp Biol Med. 1984 Sep;176(4):403-6. doi: 10.3181/00379727-176-41889.
Pregnant rats were treated with 30 mg metopirone (M) each day for 2 days and autopsied on the third day in various gestational periods (Days 18-20, 19-21, and 20-22). Control rats were treated with saline alone (S). The adrenals of intact fetuses in M-treated dams were significantly heavier than those of intact fetuses in S-treated dams in every experimental period. In both M- and S-treated dams, the adrenals of encephalectomized (E) fetuses were lighter than those of intact littermates. However, in the experimental period of Days 18-20 and 19-21, the adrenals of E fetuses in M-treated dams were slightly but significantly heavier than those of similar E fetuses in S-treated dams. In contrast, in the experimental period Days 20-22, there was no significant difference in the weight of adrenals of E fetuses of M- and S-treated dams. These changes in fetal adrenal weight were reflected histologically in parallel changes in the size of adrenocortical cells. The observations suggest that the fetal adrenal hypertrophy following maternal treatment with metopirone can occur to some extent independent of the fetal brain, but that close to the end of gestation the hypertrophy occurs completely under the control of the fetal brain.
将怀孕大鼠每天用30毫克美替拉酮（M）处理2天，并在不同孕期（第18 - 20天、第19 - 21天和第20 - 22天）的第3天进行解剖。对照大鼠仅用生理盐水处理（S）。在每个实验阶段，用M处理的母鼠所产完整胎儿的肾上腺明显比用S处理的母鼠所产完整胎儿的肾上腺重。在M处理组和S处理组的母鼠中，去脑（E）胎儿的肾上腺比同窝完整胎儿的肾上腺轻。然而，在第18 - 20天和第19 - 21天的实验阶段，用M处理的母鼠所产E胎儿的肾上腺比用S处理的母鼠所产类似E胎儿的肾上腺略重但差异显著。相反，在第20 - 22天的实验阶段，用M处理和S处理的母鼠所产E胎儿的肾上腺重量没有显著差异。胎儿肾上腺重量的这些变化在组织学上反映为肾上腺皮质细胞大小的平行变化。这些观察结果表明，母体用美替拉酮处理后胎儿肾上腺肥大在一定程度上可以独立于胎儿脑发生，但在妊娠末期，肥大完全在胎儿脑的控制下发生。
