Bonerandi J J, Baran R, Breton A, Bourdet D
Ann Dermatol Venereol. 1978 Jan;105(1):67-72.
Comparative study of achromic and normally pigmented skin of three piebald patients from two families is reported here. DOPA-positive cells were not seen in the achromic areas, but the number of ATPase sites appeared to be normal; therefore the assumption of the replacement of the melanocytes by Langerhans cells cannot be supported. Through electron microscope, Langerhans cells looked strictly normal. Melanosomes appeared reduced in size and some alterations were noticed in their shape and contents. Ultrastructurally, a more prominent change consisted in increased undefined clear cells in the achromic skin. These dendritic suprabasal cells were devoid of melanosomes or Langerhans granules and might represent undifferentiated melanocytes. These features were discussed according to previous literature.
本文报道了来自两个家族的三名斑驳病患者的无色皮肤和正常色素沉着皮肤的比较研究。在无色区域未发现多巴阳性细胞，但ATP酶位点的数量似乎正常；因此，朗格汉斯细胞替代黑素细胞的假设不成立。通过电子显微镜观察，朗格汉斯细胞看起来完全正常。黑素小体尺寸减小，并且在其形状和内容物方面发现了一些改变。超微结构上，更显著的变化是无色皮肤中未定义的透明细胞增加。这些树突状基底上层细胞没有黑素小体或朗格汉斯颗粒，可能代表未分化的黑素细胞。根据先前的文献对这些特征进行了讨论。
