长期服用二氢麦角毒碱会影响大鼠纹状体中多巴胺识别位点的数量。

Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum.

作者信息

Battaini F, Govoni S, Rius R A, Spano P F, Trabucchi M

出版信息

Pharmacol Res Commun. 1984 Jun;16(6):605-11. doi: 10.1016/s0031-6989(84)80040-5.

DOI:10.1016/s0031-6989(84)80040-5

Abstract

Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's disease, amenorrhea-galactorrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.

摘要

麦角衍生物已被提出在各种据信多巴胺能传递受损的病理状况中具有改善作用，即帕金森病、闭经-溢乳综合征以及老年行为障碍的治疗。为了更深入了解麦角衍生物对多巴胺受体的直接作用可能产生的影响，我们研究了急性和慢性双氢麦角毒碱（DHT）处理对3H-螺哌啶醇和3H-N-丙基去甲阿朴吗啡（3H-NPA）与大鼠纹状体膜制剂结合的影响。结果表明，无论是急性还是慢性处理后，麦角衍生物均与多巴胺识别位点存在相互作用。

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Pharmacol Res Commun. 1984 Jun;16(6):605-11. doi: 10.1016/s0031-6989(84)80040-5.

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J Neurochem. 1981 Jan;36(1):201-19. doi: 10.1111/j.1471-4159.1981.tb02396.x.

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