Dumont Y, Larose L, Poirier G G, Morisset J
Pharmacology. 1984;29(1):40-6. doi: 10.1159/000137990.
This study was undertaken to establish if there is a correlation between the ontogenesis of cholinesterase activities and the cholinergic muscarinic receptors in the development of rat pancreas. Two different cholinesterase activities were detected in the pancreas: a true acetylcholinesterase and a pseudocholinesterase. The ratio of acetylcholinesterase to total cholinesterase activities varied as a function of age. Acetylcholinesterase and total cholinesterase specific activities (units per milligram protein) decreased sharply at weaning. When expressed on a DNA basis, both activities decreased constantly until age 30 days to increase slightly thereafter. However, a correlation could not be established between the development of acetylcholinesterase activity and the muscarinic receptors.
本研究旨在确定大鼠胰腺发育过程中胆碱酯酶活性的个体发生与胆碱能毒蕈碱受体之间是否存在相关性。在胰腺中检测到两种不同的胆碱酯酶活性：真性乙酰胆碱酯酶和假性胆碱酯酶。乙酰胆碱酯酶与总胆碱酯酶活性的比值随年龄而变化。断奶时，乙酰胆碱酯酶和总胆碱酯酶的比活性（每毫克蛋白质的单位数）急剧下降。以DNA为基础表示时，两种活性在30日龄前持续下降，此后略有增加。然而，乙酰胆碱酯酶活性的发育与毒蕈碱受体之间未能建立相关性。
