Schaeffer C, Aron C
Physiol Behav. 1984 Mar;32(3):457-61. doi: 10.1016/0031-9384(84)90263-4.
The aim of this work was to study the influence of the hormonal milieu on the facilitory effects of olfactory stimuli originating from female urine on lordosis behavior in orchidectomized (ORCH) feminized rats. Urine from ovariectomized (OVX) rats was shown to increase the proportion of ORCH rats displaying lordosis behavior, an effect which was enhanced if the OVX rats had been given progesterone. Treatment of OVX rats with estradiol benzoate did not affect the pheromonal activity of their urine. Dexamethasone treatment of OVX rats completely suppressed the facilitory effects of their urine on the feminine behavior in males. A higher proportion of feminized rats displayed lordosis following exposure to urine collected from pseudopregnant rats than did their unexposed counterparts. Dexamethasone treatment of pseudopregnant rats did not abolish this effect. These results suggest that the adrenal cortex is capable, in the absence of the ovaries, of manufacturing some pheromonal substance which stimulates feminine behavior in the male rat. The nature of this substance remains unknown. Furthermore progesterone itself is involved in the emission of olfactory signals which control feminine behavior in the male rat.
本研究旨在探讨激素环境对源自雌性尿液的嗅觉刺激在去势（ORCH）雌性化大鼠中对脊柱前凸行为促进作用的影响。研究表明，来自卵巢切除（OVX）大鼠的尿液能增加表现出脊柱前凸行为的ORCH大鼠的比例，若给OVX大鼠注射孕酮，此效应会增强。用苯甲酸雌二醇处理OVX大鼠并不影响其尿液的信息素活性。用地塞米松处理OVX大鼠可完全抑制其尿液对雄性大鼠雌性行为的促进作用。与未接触的雌性化大鼠相比，接触假孕大鼠尿液的雌性化大鼠中表现出脊柱前凸的比例更高。用地塞米松处理假孕大鼠并不能消除这种效应。这些结果表明，在没有卵巢的情况下，肾上腺皮质能够产生某种刺激雄性大鼠雌性行为的信息素物质。该物质的性质尚不清楚。此外，孕酮本身参与了控制雄性大鼠雌性行为的嗅觉信号的释放。
