Poberezkina D Ia, Ivashina S A
Antibiotiki. 1978 Apr;23(4):321-5.
Data on the dynamic examination of persons being in professional contact with grizin, an antibiotic used as a food additive are presented. It was shown that contact with grizin resulted in changes in the humoral, cell and barrier factors of the non-specific immunity. The trends of the changes and their manifestations were different depending on the age, period and contact level. The levels of lysozyme, absorption and digestion activity of the neutrophils provided differentiation of the adaptive reactions and phenomena of frustation in the compensatory mechanism. The methods used in the study allowed the authors to detect changes in the state of the nonspecific immunological reactivity of the persons being in contact with grizin before the appearance of the clinicaly pronounced forms of the pathology.
本文呈现了与用作食品添加剂的抗生素格日新有职业接触人员的动态检查数据。结果表明，与格日新接触会导致非特异性免疫的体液、细胞和屏障因子发生变化。这些变化的趋势及其表现因年龄、接触时期和接触水平而异。溶菌酶水平、中性粒细胞的吞噬和消化活性为代偿机制中适应性反应和应激现象的区分提供了依据。该研究中使用的方法使作者能够在出现明显临床病理形式之前检测出与格日新接触人员的非特异性免疫反应状态的变化。
