Greenlees K J, Tucker A
Respiration. 1984;45(3):169-74. doi: 10.1159/000194615.
Male Sprague-Dawley rats were exposed to 6, 3 or 1 h of simulated high altitude (380 Torr). The isolated perfused lung of each animal was challenged with 4 sequential periods of hypoxia, angiotensin II (AII), and 5-hydroxytryptamine (5-HT) following altitude exposure. Isolated perfused lungs of low altitude control rats were similarly challenged. The acute hypoxic vasoconstrictor response was significantly reduced in animals exposed to 3 and 6 h of high altitude compared to low altitude control animals. The hypoxic pressor response was not significantly different from control in animals exposed to 1 h of simulated altitude. Pressor responses to AII and 5-HT following altitude exposure were not significantly different from controls.
将雄性斯普拉格-道利大鼠暴露于模拟高海拔（380托）环境6小时、3小时或1小时。在海拔暴露后，对每只动物的离体灌注肺进行4个连续阶段的低氧、血管紧张素II（AII）和5-羟色胺（5-HT）刺激。对低海拔对照大鼠的离体灌注肺进行类似刺激。与低海拔对照动物相比，暴露于高海拔3小时和6小时的动物急性低氧性血管收缩反应显著降低。暴露于模拟海拔1小时的动物的低氧升压反应与对照无显著差异。海拔暴露后对AII和5-HT的升压反应与对照无显著差异。
