Bransom C J, Boxer M E, Clark J C, Smith J A, Johnson A G
Scand J Gastroenterol. 1984 Jun;19(4):515-20.
Epithelial cell proliferation in the duodenum was investigated in 50 patients by incubating mucosal biopsy samples with tritiated thymidine, followed by autoradiography. Fifteen patients had a normal duodenum, 15 duodenal ulcer undergoing elective surgery, 10 perforated duodenal ulcer, and 5 severe non-ulcer-associated duodenitis. The mean crypt cell labelling index in the duodenal bulb of controls was 8.8 +/- 0.4% (mean +/- SEM), at the edge of perforated ulcers 19.1 +/- 2.0%, at the edge of elective ulcers 18.6 +/- 1.4%, and in biopsy specimens from non-ulcer-associated duodenitis 14.0 +/- 1.2%. The mean labelling index in the distal first part of duodenum of control patients was 9.1 +/- 0.8 similar to the values found in histologically normal specimens distal to ulcer or duodenitis. The results indicate active epithelial cell proliferation in both duodenal ulcer and duodenitis. There was no evidence of impairment of epithelial cell proliferation in duodenal ulcer patients.
通过用氚标记的胸腺嘧啶核苷孵育黏膜活检样本，随后进行放射自显影，对50例患者十二指肠的上皮细胞增殖情况进行了研究。15例患者十二指肠正常，15例十二指肠溃疡患者接受择期手术，10例十二指肠溃疡穿孔患者，5例重度非溃疡相关性十二指肠炎患者。对照组十二指肠球部隐窝细胞标记指数平均为8.8±0.4%（平均值±标准误），溃疡穿孔边缘为19.1±2.0%，择期溃疡边缘为18.6±1.4%，非溃疡相关性十二指肠炎活检标本为14.0±1.2%。对照患者十二指肠第一段远端的平均标记指数为9.1±0.8，与溃疡或十二指肠炎远端组织学正常标本中的值相似。结果表明十二指肠溃疡和十二指肠炎中上皮细胞均有活跃增殖。没有证据表明十二指肠溃疡患者上皮细胞增殖受损。
