人类c-myc癌基因所表达蛋白质的核定位及DNA结合特性
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene.
作者信息
Persson H, Leder P
出版信息
Science. 1984 Aug 17;225(4663):718-21. doi: 10.1126/science.6463648.
PMID:6463648
Abstract
Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.
摘要
使用针对人细胞原癌基因myc产物的抗血清来鉴定一种分子量为65,000的人c-myc特异性蛋白。亚细胞分级分离显示，人c-myc蛋白主要存在于细胞核中。通过DNA亲和色谱分析测定，p65Kc-myc蛋白可与双链和单链DNA结合。
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