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感染不同株布氏锥虫的小型猪的组织病理学发现。

Histopathological findings in mini-pigs infected with different strains of Trypanosoma brucei.

作者信息

Büngener W, Mehlitz D

出版信息

Tropenmed Parasitol. 1984 Jun;35(2):109-14.

PMID:6464185
Abstract

Two pigs infected with Trypanosoma brucei gambiense developed low parasitemia which became undetectable after 6 months; on autopsy 13 months after infection they showed no histopathological alterations. --Five of six pigs infected with a Trypanosoma brucei brucei strain from the Ivory Coast developed low parasitemia (up to about antilog 6.5 per ml of blood) which became progressively lower but was detectable up to one year after infection. On autopsy they showed interstitial myocarditis and meningo-encephalitis; during the course of the infection, the first became milder, the second more intense; no trypanosomes were seen in the tissues. One of these pigs developed a parasitemia of up to antilog 8 and died 172 days after infection from bacterial pneumonia, histologically it had severe myocarditis with many trypanosomes in the tissue and mild meningo-encephalitis. --Three pigs infected with a Trypanosoma brucei brucei strain from the Serengeti died 47, 68, 130 days after infection. The first dying pig had a high terminal parasitemia, in the others, the parasitemia was low until the end, being only detectable by the hematocrit centrifugation technique or by mouse passage. At autopsy, all showed massive myocarditis and interstitial nephritis with masses of extravascular trypanosomes, moderate meningo-encephalitis with very few trypanosomes, and widespread colonization of other organs and tissues by trypanosomes, still without marked cellular infiltrations.

摘要

两只感染了布氏冈比亚锥虫的猪出现了低虫血症,6个月后虫血症变得无法检测到;在感染13个月后进行尸检时,它们没有显示出组织病理学改变。——六只感染了来自象牙海岸的布氏布氏锥虫菌株的猪中有五只出现了低虫血症(每毫升血液中高达约对数6.5),虫血症逐渐降低,但在感染后长达一年的时间里仍可检测到。尸检时,它们显示出间质性心肌炎和脑膜脑炎;在感染过程中,前者变得较轻,后者变得更严重;在组织中未发现锥虫。其中一只猪的虫血症高达对数8,并在感染172天后死于细菌性肺炎,组织学检查显示其患有严重的心肌炎,组织中有许多锥虫,还有轻度的脑膜脑炎。——三只感染了来自塞伦盖蒂的布氏布氏锥虫菌株的猪在感染后47、68、130天死亡。第一只死亡的猪在末期有高虫血症,其他猪的虫血症一直很低,直到最后,只能通过血细胞比容离心技术或通过小鼠传代检测到。尸检时,所有猪都显示出大面积的心肌炎和间质性肾炎,有大量血管外锥虫,中度脑膜脑炎,锥虫极少,锥虫在其他器官和组织中广泛定植,仍然没有明显的细胞浸润。

相似文献

1
Histopathological findings in mini-pigs infected with different strains of Trypanosoma brucei.感染不同株布氏锥虫的小型猪的组织病理学发现。
Tropenmed Parasitol. 1984 Jun;35(2):109-14.
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[Behavior of a Trypanosoma brucei strain (STIB 348C) in mice. 3. Histopathological findings in the terminal stage of infection].[布氏锥虫菌株(STIB 348C)在小鼠体内的行为。3. 感染末期的组织病理学发现]
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Behaviour of a Trypanosoma brucei brucei stock (STIB 348C) in mice. 4. Different course of primary parasitemia in trypanosome variants of different virulence.布氏布氏锥虫株(STIB 348C)在小鼠体内的行为。4. 不同毒力的锥虫变体中初次寄生虫血症的不同病程。
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Behaviour of a Trypanosoma brucei brucei stock (STIB 348C) in mice. 2. Course of infections with the basic type and several variant types.布氏布氏锥虫株(STIB 348C)在小鼠体内的行为。2. 基础型及几种变异型的感染过程。
Tropenmed Parasitol. 1982 Dec;33(4):243-8.
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A model for cardiopathy induced by Trypanosoma brucei brucei in mice. A histologic and immunopathologic study.布氏布氏锥虫诱导小鼠心脏病的模型。组织学和免疫病理学研究。
Am J Pathol. 1980 May;99(2):325-52.
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Exp Parasitol. 1997 Feb;85(2):183-92. doi: 10.1006/expr.1996.4136.
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The course of Trypanosoma brucei ssp. infection in domestic chickens.布氏锥虫亚种在家鸡体内的感染过程。
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On the persistence of human serum resistance and isoenzyme patterns of Trypanozoon in experimentally infected pigs.关于实验感染猪体内人体血清抗性和锥虫同工酶模式的持续性
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