Klimov A N
Ukr Biokhim Zh (1978). 1984 May-Jun;56(3):345-54.
Modern ideas on interaction of blood plasma lipoproteins with a cell and lipid transport to and out of the cell are considered. Receptor-mediated uptake of low-density lipoproteins by the parenchymatous and connective-tissue type cells as well as nonregulated endocytic uptake of native and modified lipoproteins by the macrophagal type cells are shown to play a certain part in maintaining cholesterol homeostasis in the organism. Characterization is given for conditions under which there occur accumulation of lipoprotein cholesterol in a cell and formation of a foamy cell a "precursor and companion" of the atherosclerotic affection of arteries.
本文探讨了现代关于血浆脂蛋白与细胞相互作用以及脂质进出细胞转运的观点。实质细胞和结缔组织型细胞通过受体介导摄取低密度脂蛋白，巨噬细胞型细胞对天然和修饰脂蛋白的非调节性内吞摄取，在维持机体胆固醇稳态中发挥了一定作用。文中还描述了细胞内脂蛋白胆固醇积累以及形成泡沫细胞（动脉粥样硬化病变的“前体和伴随物”）的条件。
