Mikata A, Suzuki S, Suzuki H, Higo O, Shimoyama M
Ultrastruct Pathol. 1984;6(2-3):161-6. doi: 10.3109/01913128409018570.
A case of lymphoid hyperplasia with prominent plasmacytic proliferation histologically and with polyclonal hypergammaglobulinemia and anemia clinically was reported. This condition in a 54-year-old Japanese male was probably a type of plasma cell dyscrasia similar to a plasma cell variant of Castleman's disease. About 19% of apparently nonatypical lymphocytes in the biopsy material of this case were found to have ribosome-lamella complexes (RLC) similar to those previously described in patients with hairy cell leukemia and some other hematologic disorders. An intimate association with the rough endoplasmic reticulum of these structures suggested aberrant protein synthesis by B-lymphocytes.
报告了一例组织学上以显著浆细胞增生为特征的淋巴样增生病例，临床上伴有多克隆高球蛋白血症和贫血。该54岁日本男性的这种病症可能是一种浆细胞发育异常，类似于Castleman病的浆细胞变异型。在该病例的活检材料中，约19%明显无异常的淋巴细胞被发现具有核糖体板层复合物（RLC），类似于先前在毛细胞白血病患者和其他一些血液系统疾病中所描述的那些。这些结构与粗面内质网的紧密联系提示B淋巴细胞存在异常蛋白质合成。
