Gilchrist K W, Hogan T F, Harberg J, Sonneland P R
Urology. 1984 Aug;24(2):122-4. doi: 10.1016/0090-4295(84)90410-2.
Nuclear grading has been reported to be a useful prognostic indicator in renal cell carcinoma (RCC). One of the components of nuclear grading, the size or cross-sectional area of cancerous nuclei, might by itself be a determinant of biologic behavior in RCC. To examine this possibility, a retrospective qualitative analysis of clinical and histopathologic parameters in 32 patients with Robson Stage 3 RCC was conducted. Patients with disproportionately larger nuclei in their RCC cells had a statistically shorter median survival (p less than 0.009). The examination of the relative areas of cancerous nuclei, herein termed nuclear sizing, appears to be a prognostic discriminant in primary RCC.
据报道，核分级是肾细胞癌（RCC）中一种有用的预后指标。核分级的组成部分之一，即癌细胞核的大小或横截面积，其本身可能是肾细胞癌生物学行为的一个决定因素。为了检验这种可能性，对32例罗布森3期肾细胞癌患者的临床和组织病理学参数进行了回顾性定性分析。肾癌细胞核 disproportionately 较大的患者，其统计学中位生存期较短（p小于0.009）。对癌细胞核相对面积的检测，在此称为核大小测定，似乎是原发性肾细胞癌的一种预后判别指标。 （注：原文中“disproportionately”未准确翻译，可结合上下文进一步优化表述，比如“不成比例地” ）
