Till U, Arese P, Bosia A, Danz R, Hofmann B, Hofmann J, Lösche W, Meyer M, Ostermann G, Pescarmona G P
Z Gesamte Inn Med. 1984 May 15;39(10):227-32.
The activation of the blood platelets is the prerequisite for their participation in physiological and pathological intravasal processes. An aimed influence on the distinct functions of the blood platelets presumes an exact knowledge about course and regulation of the activation of the platelets. Investigations on glucose-6-phosphate-dehydrogenase-deficient platelets and on the effect of glutathione-oxidizing substances on normal platelets showed references to a regulatory significance of the cellular thiol/disulphide state in the process of activation. In this case particularly the arachidonic acid balance and the SH/SS-state of platelet proteins seem to be in close connection with reductive ways of metabolism.
血小板的激活是其参与生理和病理血管内过程的前提条件。对血小板不同功能的针对性影响需要对血小板激活的过程和调节有确切的了解。对葡萄糖-6-磷酸脱氢酶缺乏的血小板以及谷胱甘肽氧化物质对正常血小板影响的研究表明，细胞硫醇/二硫键状态在激活过程中具有调节意义。在这种情况下，特别是花生四烯酸平衡和血小板蛋白质的SH/SS状态似乎与还原性代谢途径密切相关。
