Ritsner M S, Karas' S I, Toĭtman L L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(6):810-3.
With the help of genetic-dispersion analysis the authors studied a series of phenotypes, using both their own familial records (232 families, 5060 relatives of the I-III degree of kinship) as well as those of other researchers (570 families, 18415 relatives of the I-III degree of kinship). The results have shown that the contribution of the genetic and environmental factors to the determination of epilepsy constitutes 5% and 95% in the alternative phenotype model and 65% and 35% in the quasi-continuous phenotype model, respectively. The degree of the genetic factors involvement in the development of phenotypes of "genuine" and "centroencephalic" epilepsy increases irrespective of the phenotype model. The authors also present their outlook on further developments of the genetic dispersion analysis in the research of multifactorial mental diseases.
借助遗传离散度分析，作者研究了一系列表型，使用了他们自己的家族记录（232个家族，5060名一级至三级亲属）以及其他研究人员的记录（570个家族，18415名一级至三级亲属）。结果表明，在替代表型模型中，遗传因素和环境因素对癫痫决定的贡献分别为5%和95%，在准连续表型模型中分别为65%和35%。无论表型模型如何，遗传因素参与“真性”和“中央脑性”癫痫表型发展的程度都在增加。作者还阐述了他们对遗传离散度分析在多因素精神疾病研究中进一步发展的展望。
