系统性红斑狼疮。一项前瞻性分析。
Systemic lupus erythematosus. A prospective analysis.
作者信息
Grigor R, Edmonds J, Lewkonia R, Bresnihan B, Hughes G R
出版信息
Ann Rheum Dis. 1978 Apr;37(2):121-8. doi: 10.1136/ard.37.2.121.
Abstract
The spectrum of organ involvement in 50 patients with systemic lupus erythematosus has been assessed in a prospective study. All patients were admitted to hospital electively for 2 days and a complete clinical and laboratory assessment protocol completed. Subsequent hospital admissions depended on clinical status. The overall mean observation period was 29 months. Widespread multisystem involvement was found in every patient. Subclinical abnormalities of respiratory and cerebral function were common even in patients in clinical remission. A more conservative approach than has been generally recommended was used for the management of systemic lupus erythematosus and is supported by the estimated 5-year survival of 98%.
摘要
一项前瞻性研究评估了50例系统性红斑狼疮患者的器官受累情况。所有患者均择期入院2天，并完成了完整的临床和实验室评估方案。随后的住院情况取决于临床状况。总体平均观察期为29个月。发现每位患者均有广泛的多系统受累。即使在临床缓解的患者中，呼吸和脑功能的亚临床异常也很常见。对于系统性红斑狼疮的治疗，采用了一种比通常推荐的更为保守的方法，估计5年生存率为98%，这支持了该方法。
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