Furman J M, O'Leary D P, Wolfe J W
Acta Otolaryngol. 1984 May-Jun;97(5-6):627-32. doi: 10.3109/00016488409132940.
Vestibular induced nystagmus in the dark was measured during sinusoidal rotational stimulation in three male monkeys using electrooculography. A periodic modulation of mean eye position was observed. This periodic modulation was quantified by least squares fitting through the nystagmus a sinusoid whose frequency was the same as that of the stimulus. The magnitude and the phase of the best fitting sinusoid were used to determine gain and phase delay at various combinations of stimulus amplitudes and frequency. Results indicate that the mean eye position in the alert animals is predominantly modulated in the direction of the fast component of nystagmus. The magnitude of this modulation of mean eye position is independent of the amplitude of the stimulus. The phase relationship of this modulation is dependent on the frequency of stimulation. In drowsy animals, the modulation of mean eye position is predominantly in the direction of the slow component of nystagmus. We conclude that the modulation of mean eye position during vestibular induced nystagmus operates as an automatic gain control system which is sensitive to the animal's level of alertness. The quantitative data in this report are useful in refining current models of vestibular nystagmus.
在黑暗环境中，使用眼电图对三只雄性猴子进行正弦旋转刺激时，测量前庭诱发的眼球震颤。观察到平均眼位的周期性调制。通过对眼球震颤进行最小二乘拟合来量化这种周期性调制，拟合出一个频率与刺激频率相同的正弦波。最佳拟合正弦波的幅度和相位用于确定在不同刺激幅度和频率组合下的增益和相位延迟。结果表明，警觉动物的平均眼位主要在前庭眼球震颤快相方向上受到调制。平均眼位这种调制的幅度与刺激幅度无关。这种调制的相位关系取决于刺激频率。在困倦动物中，平均眼位的调制主要在前庭眼球震颤慢相方向上。我们得出结论，前庭诱发眼球震颤期间平均眼位的调制作为一种自动增益控制系统，对动物的警觉水平敏感。本报告中的定量数据有助于完善当前的前庭眼球震颤模型。
