Inai K, Ohe K, Tokuoka S, Miyachi Y
Acta Pathol Jpn. 1984 May;34(3):693-704. doi: 10.1111/j.1440-1827.1984.tb07598.x.
A case of adrenocortical carcinoma with feminization seen in a man aged 35, is reported. The levels of estron (E1) and estradiol (E2) in the venous blood draining the tumor were high, and it was confirmed by in vitro assay of tumor cells taken from the primary tumor of the left adrenal gland that the tumor produced estrone. The light microscopic examination demonstrated that the primary tumor was composed of mixture of large cells with pleomorphic nuclei and vacuolated cytoplasm and uniform cells with ovoid nuclei and eosinophilic cytoplasm. The electron microscopic examination on the latter cells revealed numerous large and irregularly shaped mitochondria with mostly tubular or lamellar and occasionally vesicular cristae and electron-dense matrix, well-developed smooth-surfaced endoplasmic reticulum in the cytoplasm. However, lipid droplets and lysosomes or lipofuscin granules were scanty. From these findings, it is suggested that cells of the present tumor have characteristics of those in the zona reticularis of the adrenal cortex as well as in the fetal cortex, and the functional property of this tumor is well correlated with its morphological features.
报告了一例35岁男性肾上腺皮质癌伴女性化的病例。引流肿瘤的静脉血中雌酮（E1）和雌二醇（E2）水平较高，通过对取自左肾上腺原发性肿瘤的肿瘤细胞进行体外检测，证实该肿瘤产生雌酮。光镜检查显示，原发性肿瘤由核多形性的大细胞和胞质空泡化的细胞以及核椭圆形、胞质嗜酸性的均匀细胞混合组成。对后一种细胞的电镜检查发现大量大的、形状不规则的线粒体，其嵴大多为管状或板层状，偶尔为泡状，基质电子密度高，胞质中有发达的滑面内质网。然而，脂滴、溶酶体或脂褐素颗粒较少。从这些发现来看，提示该肿瘤细胞具有肾上腺皮质网状带细胞以及胎儿皮质细胞的特征，并且该肿瘤的功能特性与其形态特征密切相关。
