摄入各种维生素E制剂后血清α-生育酚浓度。
Serum concentrations of alpha-tocopherol after ingestion of various vitamin E preparations.
作者信息
Horwitt M K, Elliott W H, Kanjananggulpan P, Fitch C D
出版信息
Am J Clin Nutr. 1984 Aug;40(2):240-5. doi: 10.1093/ajcn/40.2.240.
The rat-fetal-resorption test currently is used to assess the biological activity of vitamin E compounds. Previous studies in humans, however, suggest that rat assays underestimate the potency of free tocopherol relative to the acetate ester form and of RRR-alpha-tocopheryl acetate relative to all-rac-alpha-tocopheryl acetate. Therefore, we studied the serum concentrations of alpha-tocopherol after ingestion of RRR-alpha-tocopheryl acetate, all-rac-alpha-tocopheryl acetate, RRR-alpha-tocopherol, RRR-alpha-tocopheryl succinate, and RRR-alpha-tocopheryl acetate plus apple pectin by each of 20 adult human subjects. Measurements were made at 0, 8, 24, and 48 h after ingestion of 800 IU of the various preparations. The results at 24 h were representative of the differences observed. The mean increase in concentration of alpha-tocopherols (mg/g lipid) in 24 h was 71.2% after RRR-alpha-tocopherol, 63.3% after RRR-alpha-tocopherol acetate, and 41.2% after RRR-alpha-tocopherol succinate. Animal assay data do not correlate with data from studies of absorption and retention in serum of alpha-tocopherols ingested by humans.
大鼠胚胎吸收试验目前用于评估维生素E化合物的生物活性。然而，先前的人体研究表明，大鼠试验低估了游离生育酚相对于醋酸酯形式的效力，以及RRR-α-生育酚醋酸酯相对于消旋-α-生育酚醋酸酯的效力。因此，我们研究了20名成年受试者分别摄入RRR-α-生育酚醋酸酯、消旋-α-生育酚醋酸酯、RRR-α-生育酚、RRR-α-生育酚琥珀酸酯以及RRR-α-生育酚醋酸酯加苹果果胶后血清中α-生育酚的浓度。在摄入800 IU各种制剂后的0、8、24和48小时进行测量。24小时的结果代表了观察到的差异。24小时内α-生育酚浓度（mg/g脂质）的平均增加量在RRR-α-生育酚后为71.2%，在RRR-α-生育酚醋酸酯后为63.3%，在RRR-α-生育酚琥珀酸酯后为41.2%。动物试验数据与人体摄入α-生育酚后血清中吸收和保留的研究数据不相关。
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