Coccaro E F, Prudic J, Rothpearl A, Nurnberg H G
Am J Psychiatry. 1984 Aug;141(8):982-5. doi: 10.1176/ajp.141.8.982.
The authors examined the dexamethasone suppression test (DST) responses of 41 patients with primary major depressive disorder and 40 patients with other psychiatric disorders who were tested within 2-6 days of hospital admission. Significantly more patients with primary depression who were tested on day 2 demonstrated abnormal cortisol suppression than those who were tested on days 3, 4, or 3-6 and than patients with other psychiatric disorders regardless of test day. These results suggest that patients with primary depression may be sensitive to psychophysiologic stresses associated with hospital admission and that the utility of the DST may require further evaluation vis-à-vis the day of DST administration.
作者对41例原发性重度抑郁症患者和40例其他精神障碍患者的地塞米松抑制试验（DST）反应进行了检查，这些患者均在入院后2 - 6天内接受测试。与在第3天、第4天或第3 - 6天接受测试的原发性抑郁症患者相比，以及与无论测试日期如何的其他精神障碍患者相比，在第2天接受测试的原发性抑郁症患者中，表现出异常皮质醇抑制的患者明显更多。这些结果表明，原发性抑郁症患者可能对与入院相关的心理生理应激敏感，并且DST的效用可能需要根据DST给药的日期进行进一步评估。
