Pfefferbaum-Levine B, Copeland D R, Fletcher J M, Ried H L, Jaffe N, McKinnon W R
Am J Pediatr Hematol Oncol. 1984 Summer;6(2):123-8. doi: 10.1097/00043426-198406020-00002.
Thirty-two long-term survivors of childhood leukemia who were followed up at the University of Texas M. D. Anderson Hospital were evaluated with a battery of 17 neuropsychologic tests. These tests were selected to assess the development of cognitive skills and functions associated with brain impairment in children. Statistically significant differences were found between the group of children given CNS irradiation and the nonirradiated group on full-scale IQ and verbal IQ scores, mathematics skills, constructional skills, and memory for spatial material. Of particular interest was the absence of differences in language-based measures of verbal memory and the presence of group differences on measures of memory for spatial material. While the sample size was small, the findings delineate specific areas likely to be affected. These results indicate the need for caution when including cranial irradiation in CNS prophylaxis. When any CNS treatment is given, it seems appropriate that provisions be made for assessment and remediation of affected skills.
在德克萨斯大学MD安德森医院接受随访的32名儿童白血病长期幸存者，接受了一系列17项神经心理学测试的评估。选择这些测试是为了评估与儿童脑损伤相关的认知技能和功能的发展。在接受中枢神经系统放疗的儿童组和未接受放疗的儿童组之间，在全量表智商和言语智商得分、数学技能、建构技能以及对空间材料的记忆方面发现了具有统计学意义的差异。特别值得关注的是，基于语言的言语记忆测量方法没有差异，而在空间材料记忆测量方法上存在组间差异。尽管样本量较小，但研究结果明确了可能受影响的具体领域。这些结果表明，在中枢神经系统预防中进行颅脑照射时需要谨慎。当进行任何中枢神经系统治疗时，为受影响技能的评估和补救做出安排似乎是合适的。
