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Perineal reconstruction in ambiguous genitalia infants raised as females.

作者信息

Donahoe P K, Hendren W H

出版信息

Ann Surg. 1984 Sep;200(3):363-71. doi: 10.1097/00000658-198409000-00014.

DOI:10.1097/00000658-198409000-00014
PMID:6465986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1250489/
Abstract

Sixty-six patients with ambiguous genitalia, representing a combined experience, underwent reconstruction of the perineum to achieve a feminine phenotype. These patients represent four major etiologic groups, adrenogenital syndrome, male pseudohermaphroditism, mixed gonadal dysgenesis, and true hermaphroditism. If the patient is to be raised as a female, the perineum is reconstructed early in the neonatal period by doing a clitoral recession, labial reduction, and vaginal exteriorization. The latter is delayed if the vagina enters the urogenital sinus high, until 2 years. The factors affecting the choice of gender and the details and the timing of the surgical techniques are described.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/622804b6c148/annsurg00115-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/51e92cf89f71/annsurg00115-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/baebd7d04a6e/annsurg00115-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/622804b6c148/annsurg00115-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/51e92cf89f71/annsurg00115-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/baebd7d04a6e/annsurg00115-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca6/1250489/622804b6c148/annsurg00115-0146-a.jpg

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Perineal reconstruction in ambiguous genitalia infants raised as females.
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引用本文的文献

1
Feminizing surgical management of intersex patients.两性畸形患者的女性化手术治疗
Pediatr Surg Int. 2004 Jul;20(7):543-7. doi: 10.1007/s00383-004-1208-5. Epub 2004 Jun 19.
2
True hermaphroditism: geographical distribution, clinical findings, chromosomes and gonadal histology.真两性畸形:地理分布、临床发现、染色体及性腺组织学
Eur J Pediatr. 1994 Jan;153(1):2-10. doi: 10.1007/BF02000779.
3
The surgical management of infants and children with ambiguous genitalia. Lessons learned from 25 years.婴幼儿两性畸形的外科治疗。25年经验总结。

本文引用的文献

1
HERMAPHRODITISM WITH "ATYPICAL" OR "MIXED" GONADAL DYSGENESIS. RELATIONSHIP TO GONADAL NEOPLASM.伴有“非典型”或“混合性”性腺发育不全的两性畸形。与性腺肿瘤的关系。
Am J Med. 1964 Feb;36:281-92. doi: 10.1016/0002-9343(64)90091-9.
2
The adrenogenital syndrome.肾上腺性征异常综合征
N Engl J Med. 1963 Jun 6;268:1283-9 contd. doi: 10.1056/NEJM196306062682308.
3
Reconstructive problems of the vagina and the female urethra.
Clin Plast Surg. 1980 Apr;7(2):207-34.
Ann Surg. 1992 Jun;215(6):644-53. doi: 10.1097/00000658-199206000-00011.
4
Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases.混合性性腺发育不全综合征中睾丸及条索状性腺发育异常:来自21例临床病理分析的观点
Hum Pathol. 1982 Aug;13(8):700-16. doi: 10.1016/s0046-8177(82)80292-x.
5
An update of congenital adrenal hyperplasia.
Recent Prog Horm Res. 1981;37:105-81. doi: 10.1016/b978-0-12-571137-1.50008-6.
6
Correction of congenital abnormalities of the vagina and perineum.阴道及会阴先天性畸形的矫正。
J Pediatr Surg. 1980 Dec;15(6):751-63. doi: 10.1016/s0022-3468(80)80278-8.
7
Müllerian-inhibiting substance: an update.
Recent Prog Horm Res. 1982;38:279-330. doi: 10.1016/b978-0-12-571138-8.50013-5.
8
Preservation of gonadal function in true hermaphroditism.真两性畸形中生殖腺功能的保留
J Pediatr Surg. 1984 Feb;19(1):50-5. doi: 10.1016/s0022-3468(84)80015-9.
9
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).先天性肾上腺皮质增生症高血压型(11-β-羟化酶缺乏症)中的盐丢失
J Clin Endocrinol Metab. 1984 Feb;58(2):384-7. doi: 10.1210/jcem-58-2-384.
10
Adrenogenital syndrome: the anatomy of the anomaly and its repair. Some new concepts.
J Pediatr Surg. 1969 Feb;4(1):49-58. doi: 10.1016/0022-3468(69)90183-3.