[Dynamics of the activity of lysosomal and membrane-transport enzymes of human coronary arteries in atherosclerosis (based on specimens of early autopsy].

The time course of the activity of lysosome (LE) and membrane-transport (MTE) enzymes in the cells of human coronary arteries was studied histochemically and lipid metabolism in the plasma was studied biochemically. it is shown that the formation of atherosclerotic lesions and exacerbation of the disease in the endothelium and macrophages is followed by the enhancement of positive correlation between the atherogenic ration and the activity of LE and MTE and the alteration of this correlation between these enzymes. In the sedentary mesenchymal cells the progress of atherosclerosis results in the alteration of positive correlation between both LE and MTE and between these enzymes and atherogenic ration. Atherosclerosis remission is followed by partial restoration of the above correlations between the activity of LE and MTE in the cells of atherosclerotic lesions of the coronary arteries intima.