韦斯特综合征和伦诺克斯 - 加斯托综合征中的免疫紊乱。

Immunological disturbance in West and Lennox-Gastaut syndromes.

作者信息

Montelli T C, Mota N G, Peraçoli M T, Torres E A, Rezkallah-Iwasso M T

出版信息

Arq Neuropsiquiatr. 1984 Jun;42(2):132-9. doi: 10.1590/s0004-282x1984000200005.

DOI:10.1590/s0004-282x1984000200005

Abstract

Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of T and B peripheral blood lymphocytes, serum levels of IgG, IgA and IgM, skin sensibilization with DNCB, intracutaneous PHA, leucocyte migration inhibition test and lymphocyte blastic transformation in the presence of PHA. Cell-mediated deficiency was detected in 28 children whereas low levels of immunoglobulins were observed only in 6 children. Immunological disturbances were more prominent in children with West syndrome.

摘要

对18例韦斯特综合征患儿、12例伦诺克斯-加斯东综合征患儿和19名健康对照者进行了细胞介导免疫和体液免疫研究。该研究包括测定外周血T和B淋巴细胞、血清IgG、IgA和IgM水平、二硝基氯苯皮肤致敏试验、皮内注射PHA、白细胞游走抑制试验以及PHA存在下的淋巴细胞增殖转化试验。在28名儿童中检测到细胞介导免疫缺陷，而仅在6名儿童中观察到免疫球蛋白水平较低。免疫紊乱在韦斯特综合征患儿中更为明显。