Margolis F L, Grillo M
Biochem Genet. 1984 Jun;22(5-6):441-51. doi: 10.1007/BF00484515.
Carnosinase is a peptidase which cleaves B-alanyl-L-histidine (carnosine) and closely related dipeptides. Its activity in kidney cytosol of various mouse strains varies more than 50-fold. The highest activity occurs in random-bred CD-1 and inbred NZB/BINJ mice, while it is barely detectable in BALB/cJ, C57BL/6J, and AU/SsJ among others. Carnosinase is immunologically and enzymologically identical in all high-activity strains. This is the first report of quantitative interstrain differences in carnosinase activity. No other peptidase activity has been reported which exhibits the same strain distribution shown here. In matings and backcrosses between the NZB/BINJ and the BALB/cJ strains, the levels of kidney carnosinase activity in the progeny behave as a classical Mendelian trait.
肌肽酶是一种肽酶，可裂解β-丙氨酰-L-组氨酸（肌肽）及密切相关的二肽。其在各种小鼠品系肾细胞溶质中的活性变化超过50倍。最高活性出现在随机繁殖的CD-1和近交系NZB/BINJ小鼠中，而在BALB/cJ、C57BL/6J和AU/SsJ等小鼠中几乎检测不到。在所有高活性品系中，肌肽酶在免疫学和酶学上是相同的。这是关于肌肽酶活性品系间定量差异的首次报道。尚未有其他肽酶活性表现出此处所示的相同品系分布。在NZB/BINJ和BALB/cJ品系之间的杂交和回交中，后代肾肌肽酶活性水平表现为典型的孟德尔性状。
