Coulter D M
Biol Neonate. 1984;46(3):131-8. doi: 10.1159/000242056.
We treated neonatal rabbits from birth with exogenous prolactin or the prolactin secretagogue fluphenazine. We compared the hydration at 72 h of skeletal muscle, skin, liver, and brain to that of untreated controls. Treatment did not change the water content of liver. It increased the water content of skeletal muscle, skin, and brain. However, the response to treatment differed among these tissues. In skin and skeletal muscle, the effect of treatment was most apparent in animals whose postnatal weight gain was relatively large. In contrast, treatment increased brain water content in all animals regardless of weight gain. We conclude that much of the early postnatal decrease in skin and skeletal muscle water is due to mobilization of the neonatal tissue water reservoir, and that prolactin appears to regulate that process. Changes in brain water between birth and 72 h of age appear to result from loss of reservoir water and possibly of cerebrospinal fluid offset in part by water accretion due to tissue growth.
我们从新生兔出生起就用外源性催乳素或催乳素促分泌剂氟奋乃静对其进行治疗。我们将72小时时骨骼肌、皮肤、肝脏和大脑的水合作用与未治疗的对照组进行了比较。治疗并未改变肝脏的含水量。它增加了骨骼肌、皮肤和大脑的含水量。然而，这些组织对治疗的反应有所不同。在皮肤和骨骼肌中，治疗效果在出生后体重增加相对较大的动物中最为明显。相比之下，无论体重增加情况如何，治疗均增加了所有动物大脑的含水量。我们得出结论，出生后早期皮肤和骨骼肌水分的大量减少是由于新生儿组织水库的动员，并且催乳素似乎调节了这一过程。出生至72小时龄之间大脑水分的变化似乎是由于水库水的流失以及可能的脑脊液流失，部分被组织生长导致的水分增加所抵消。
