Meijs-Roelofs H M, Kramer P, Osman P, Sander H J
Biol Reprod. 1984 Aug;31(1):44-51. doi: 10.1095/biolreprod31.1.44.
Ovarian steroid contents and serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin were measured during the days after first ovulation in rats unilaterally ovariectomized in late prepuberty. In addition, follicle counts were made at second estrus and second metestrus. During the cycle following first ovulation, ovarian estradiol contents in unilaterally ovariectomized (ULO) rats were significantly increased as compared to intact rats on the day of metestrus, on diestrus 1 and on second estrus. Ovarian progesterone was significantly increased on the days of metestrus, on diestrus 1, second proestrus and second estrus, but no differences were seen in ovarian androgen contents. After ULO there was an indication of an augmented FSH surge at the first and the second ovulation. Follicle counts revealed that the total number of healthy as well as of atretic antral follicles on the day of second estrus was significantly increased after ULO, due to increased numbers of the smallest antral follicles. At second metestrus the number of larger antral follicles (350-500 micron 3) and the total number of healthy antral follicles was higher after ULO. It is concluded that the compensatory process after ULO involved increased recruitment of small antral follicles. Activities in the remaining ovary were not simply doubled but a new hormonal balance was established.
在青春期后期进行单侧卵巢切除的大鼠首次排卵后的几天内，测定其卵巢甾体含量以及血清促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素的浓度。此外，在第二次发情期和第二次动情后期进行卵泡计数。在首次排卵后的周期中，与完整大鼠相比，单侧卵巢切除（ULO）大鼠在动情后期、动情间期1和第二次发情期的卵巢雌二醇含量显著增加。卵巢孕酮在动情后期、动情间期1、第二次发情前期和第二次发情期的含量显著增加，但卵巢雄激素含量未见差异。单侧卵巢切除后，在第一次和第二次排卵时，促卵泡生成素峰值有增加的迹象。卵泡计数显示，单侧卵巢切除后，由于最小的窦状卵泡数量增加，在第二次发情期时健康以及闭锁窦状卵泡的总数显著增加。在第二次动情后期，单侧卵巢切除大鼠较大窦状卵泡（350 - 500微米³）的数量和健康窦状卵泡的总数更高。结论是，单侧卵巢切除后的代偿过程涉及小窦状卵泡募集增加。剩余卵巢的活动并非简单地加倍，而是建立了一种新的激素平衡。
