Golding S J, McElwain T J, Husband J E
Br J Radiol. 1984 Aug;57(680):661-6. doi: 10.1259/0007-1285-57-680-661.
Computed tomography (CT) was found to be a valuable method of assessing the extent of local disease in 36 patients with advanced neuroblastoma. Precise predictions on the operability of tumours can be made so that the timing of primary or "second look" surgery may be optimised. However, intraspinal extension of tumour is not detected on CT examinations without intrathecal contrast medium and plain radiographs are not a reliable guide to the presence of intraspinal disease; the examination should include intrathecal contrast medium (CT myelography) when patients undergo pre-operative staging by CT. The majority of neuroblastomas appear calcified on CT. During chemotherapy the most common change in tumour morphology is decrease in size and increase in calcification. There is however no correlation between tumour size or behaviour during chemotherapy and eventual survival but an increase in size during or after treatment is a serious prognostic sign.
计算机断层扫描（CT）被发现是评估36例晚期神经母细胞瘤局部病变范围的一种有价值的方法。可以对肿瘤的可切除性做出精确预测，从而优化初次手术或“二次探查”手术的时机。然而，在没有鞘内造影剂的CT检查中无法检测到肿瘤的椎管内扩展，而普通X线片对于椎管内疾病的存在并不是可靠的指导；当患者通过CT进行术前分期检查时，检查应包括鞘内造影剂（CT脊髓造影）。大多数神经母细胞瘤在CT上表现为钙化。化疗期间肿瘤形态最常见的变化是体积减小和钙化增加。然而，化疗期间肿瘤大小或行为与最终生存率之间没有相关性，但治疗期间或治疗后肿瘤大小增加是一个严重的预后指标。
