组胺作为烟碱型乙酰胆碱受体的内源性拮抗剂。

Histamine as an endogenous antagonist of nicotinic ACh-receptor.

作者信息

Ohta Y, Ariyoshi M, Koketsu K

出版信息

Brain Res. 1984 Jul 23;306(1-2):370-3. doi: 10.1016/0006-8993(84)90389-5.

Abstract

The mechanism of an inhibitory effect of histamine on the sensitivity of frog skeletal muscle endplate was analyzed by studying the dose-response relation between the quantity of ACh applied iontophoretically and the ACh-induced postsynaptic current (ACh current), and also the interaction between histamine and erabutoxin-b (ETX-b). The results obtained show that histamine, like curare, decreased the sensitivity of ACh-receptor in a competitive manner.

摘要

通过研究离子导入法施加的乙酰胆碱（ACh）量与ACh诱导的突触后电流（ACh电流）之间的剂量反应关系，以及组胺与 erabutoxin-b（ETX-b）之间的相互作用，分析了组胺对青蛙骨骼肌终板敏感性的抑制作用机制。所得结果表明，组胺与箭毒一样，以竞争性方式降低了ACh受体的敏感性。