Cohen S L, Ho P
Can J Biochem Cell Biol. 1984 Jun;62(6):547-53. doi: 10.1139/o84-072.
The tremendous interpatient variations that occur for oestrogen excretion during pregnancy are largely overcome by expressing results in terms of relative concentrations (i.e., as percent of total oestrogens excreted). Specimens of urine from 28 pregnant patients with a variety of complications were assayed for their oestrogen content by an "oestrogen profile" technique and the results thus expressed were compared with those from 20 normal pregnancies. Statistically significant changes are shown in the group of patients in the "above" normal range (normal range = normal mean +/- 3 X SE) for five oestrogens (oestrone, 2-hydroxyoestrone, 2-methoxyoestrone, 2-hydroxyoestradiol, and 2-hydroxyoestriol) and "below" the normal range for one oestrogen (oestriol). When the means of the oestrogen values for the different groups of patients were examined, two things became obvious; firstly, only patients with hypertension showed these changes, and secondly, two additional oestrogens (16-hydroxyoestrone and 16-epioestriol) were excreted in large amounts by the normotensive "high risk" patients. A comparison of the two methods of expressing oestrogen assay results is made quantitatively (as milligrams per day) versus relatively (as percent of total oestrogens excreted), and advantages and disadvantages of each are discussed.
孕期雌激素排泄存在着巨大的个体间差异，通过以相对浓度（即占总排泄雌激素的百分比）来表示结果，很大程度上克服了这一问题。采用“雌激素谱”技术对28例患有各种并发症的孕妇的尿液样本进行雌激素含量测定，并将由此得出的结果与20例正常妊娠孕妇的结果进行比较。结果显示，在“高于”正常范围（正常范围=正常均值±3×标准误）的患者组中，有5种雌激素（雌酮、2-羟雌酮、2-甲氧基雌酮、2-羟雌二醇和2-羟雌三醇）出现了具有统计学意义的变化，而在“低于”正常范围的患者组中，有一种雌激素（雌三醇）出现了变化。当检查不同患者组雌激素值的均值时，有两点变得明显；首先，只有高血压患者出现了这些变化，其次，血压正常的“高危”患者大量排泄另外两种雌激素（16-羟雌酮和16-表雌三醇）。对定量（以每天毫克数表示）和相对（以占总排泄雌激素的百分比表示）两种表示雌激素测定结果的方法进行了比较，并讨论了每种方法的优缺点。
