Jackson D V, Richards F, Spurr C L, Long T R, Rardin D A, Albertson D A, Sterchi J M
Cancer Chemother Pharmacol. 1984;13(2):120-2. doi: 10.1007/BF00257127.
Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial.
目前，可用于转移性肝癌动脉内灌注的化疗药物仅有几种。近期关于长春新碱长时间静脉输注可行性的证明，促使人们探索该药物的肝动脉内灌注。通过肝动脉导管，每天给6例转移性肝癌患者连续输注0.4mg总剂量的长春新碱，持续5天。其中5例出现了主要累及神经和胃肠道系统的短暂但危及生命的毒性反应。未来对长春新碱肝动脉内灌注的研究应基于不同于当前试验所采用的剂量方案。
