Ohnishi H, Yamaguchi K, Sato M, Uemura A, Funato H, Dabasaki T
Circ Shock. 1984;13(3):261-70.
The effects of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434) were investigated in experimental models of lethal shock produced by hemorrhage, injection of endotoxin, or coronary ligation. M6434 improved the survival rate of rabbits in hemorrhagic shock. M6434, at the dose of 3 or 10 micrograms/kg/min, completely reversed the decreases in the blood pressure and the urine output of shocked rabbits, but did not affect the decreased regional blood flow through the kidneys in the animals. Survival rates of cardiogenic-shock rats improved, and the content of ATP and creatine phosphate in myocardium of these animals were restored by the treatment with 1 or 3 micrograms/kg/min of M6434. Intravenous infusion of M6434, at a dose of 3 or 10 micrograms/kg/min for 3 hr, increased the survival rate of the endotoxin-shocked rabbits. These results indicate that M6434 may be evaluated as a possible therapeutic agent for shock.
研究了2-[(5-氯-2-甲氧基苯基)偶氮]-1H-咪唑（M6434）在出血、注射内毒素或冠状动脉结扎所致致死性休克实验模型中的作用。M6434提高了失血性休克家兔的存活率。剂量为3或10微克/千克/分钟的M6434完全逆转了休克家兔血压和尿量的下降，但对动物肾脏局部血流的减少没有影响。给予1或3微克/千克/分钟的M6434治疗，改善了心源性休克大鼠的存活率，并使这些动物心肌中的ATP和磷酸肌酸含量恢复。以3或10微克/千克/分钟的剂量静脉输注M6434 3小时，提高了内毒素休克家兔的存活率。这些结果表明，M6434可作为一种可能的抗休克治疗药物进行评估。
