伴有免疫缺陷的染色体不稳定综合征的体内抗体反应。
Antibody responses in vivo in chromosome instability syndromes with immunodeficiency.
作者信息
Weemaes C M, The T H, van Munster P J, Bakkeren J A
出版信息
Clin Exp Immunol. 1984 Sep;57(3):529-34.
Abstract
The primary IgG, IgM and IgA antibody responses to Helix pommatia haemocyanin (HPH) were defective in patients with ataxia telangiectasia (AT) and Nijmegen breakage syndrome (NBS). The results in patients with Bloom's syndrome (BS) were heterogeneous, but all showed abnormal kinetics of the IgG response. The secondary response to diphtheria, tetanus and polio vaccine was normal in patients with AT and BS, but disturbed in the patients with NBS. The abnormalities of antibody response of AT and NBS are similar, although more profound in NBS; BS is different.
摘要
共济失调毛细血管扩张症（AT）和尼美根断裂综合征（NBS）患者对玛瑙螺血蓝蛋白（HPH）的主要IgG、IgM和IgA抗体反应存在缺陷。布卢姆综合征（BS）患者的结果不一，但均显示IgG反应动力学异常。AT和BS患者对白喉、破伤风和脊髓灰质炎疫苗的二次反应正常，但NBS患者的二次反应受到干扰。AT和NBS的抗体反应异常相似，尽管在NBS中更严重；BS则不同。
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1
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3
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8
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7
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本文引用的文献
1
IMMUNOLOGIC DEFICIENCY IN ATAXIA TELANGIECTASIA.
N Engl J Med. 1965 Jan 7;272:18-22. doi: 10.1056/NEJM196501072720104.
2
[Ataxiatelangiectasis. (7 personal cases)].
Rev Neurol (Paris). 1961 Nov;105:390-405.
3
Use of color change of phenol red as the indicator in titrating poliomyelitis virus or its antibody in a tissue-culture system.
Am J Hyg. 1954 Sep;60(2):214-30. doi: 10.1093/oxfordjournals.aje.a119714.
4
A new chromosomal instability disorder: the Nijmegen breakage syndrome.
Acta Paediatr Scand. 1981 Jul;70(4):557-64. doi: 10.1111/j.1651-2227.1981.tb05740.x.
5
IgG2 deficiency in ataxia-telangiectasia.
N Engl J Med. 1982 Mar 4;306(9):515-7. doi: 10.1056/NEJM198203043060905.
6
Impaired B-cell differentiation and T-cell regulatory function in four patients with Bloom's syndrome.
Clin Immunol Immunopathol. 1982 Feb;22(2):247-58. doi: 10.1016/0090-1229(82)90041-1.
7
Immunoglobulins in ataxia-telangiectasia: evidence for IgG4 and IgA2 subclass deficiencies.
Clin Immunol Immunopathol. 1981 Jul;20(1):99-110. doi: 10.1016/0090-1229(81)90166-5.
8
Lymphocyte subpopulations in patients with various immunodeficiencies.
Acta Paediatr Scand. 1980 Mar;69(2):193-9. doi: 10.1111/j.1651-2227.1980.tb07059.x.
9
The primary immune response in patients with selective IgA deficiency.
Clin Exp Immunol. 1983 Dec;54(3):778-84.
10
Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS).
Lancet. 1982 Aug 7;2(8293):293-7. doi: 10.1016/s0140-6736(82)90271-9.
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