Fallenius A G, Skoog L K, Svane G E, Auer G U
Cytometry. 1984 Jul;5(4):426-9. doi: 10.1002/cyto.990050421.
Fifty nonpalpable, mammographically detected, invasive breast carcinomas were analysed with respect to DNA distribution pattern, steroid receptor content, and histopathological criteria. No significant histomorphological differences were found as compared to palpable breast carcinomas. In contrast, DNA distributions of palpable and nonpalpable tumors differed. Ninety percent of these relatively small breast carcinomas were found to exhibit nuclear DNA amounts within the diploid and tetraploid regions of normal breast epithelium. In earlier findings in palpable breast carcinomas, 55% are of the diploid-tetraploid type. The mean cellular content of the estrogen receptor was 1.0 fmole/microgram DNA in this group of mammographically detected carcinomas, which is significantly higher than in routinely detected, ie, larger, breast carcinomas. It is suggested that, despite the histomorphological findings, nonpalpable, mammographically detected breast carcinomas are dominated by biologically highly differentiated, slowly proliferating carcinomas with a favourable prognosis.
对50例乳腺X线检查发现的不可触及的浸润性乳腺癌进行了DNA分布模式、类固醇受体含量及组织病理学标准分析。与可触及的乳腺癌相比，未发现明显的组织形态学差异。相反，可触及和不可触及肿瘤的DNA分布有所不同。这些相对较小的乳腺癌中有90%的细胞核DNA含量在正常乳腺上皮的二倍体和四倍体区域内。在早期对可触及乳腺癌的研究结果中，55%为二倍体-四倍体类型。在这组乳腺X线检查发现的乳腺癌中，雌激素受体的平均细胞含量为1.0飞摩尔/微克DNA，这明显高于常规检测到的（即较大的）乳腺癌。提示尽管有组织形态学表现，但乳腺X线检查发现的不可触及乳腺癌主要是生物学上高度分化、增殖缓慢且预后良好的癌。
