兔脑二氢叶酸还原酶合成四氢生物蝶呤的动力学
Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.
作者信息
Abelson H T, Spector R, Gorka C, Fosburg M
出版信息
Biochem J. 1978 Apr 1;171(1):267-8. doi: 10.1042/bj1710267.
Abstract
Product identification and kinetic data are presented for the conversion of 7,8-dihydrobiopterin into tetrahydrobiopterin by purified rabbit brain dihydrofolate reductase.
摘要
给出了通过纯化的兔脑二氢叶酸还原酶将7,8 - 二氢生物蝶呤转化为四氢生物蝶呤的产物鉴定和动力学数据。
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本文引用的文献
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2
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J Biol Chem. 1972 Jul 10;247(13):4165-73.
3
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J Biol Chem. 1967 Sep 10;242(17):3934-43.
4
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Biochem Pharmacol. 1977 Aug 15;26(16):1507-11. doi: 10.1016/0006-2952(77)90423-3.
5
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